Checkpoint Therapeutics Reports Interim Results of Cosibelimab in Registration-Enabling Trial for Locally Advanced Cutaneous Squamous Cell Carcinoma
Shots:
- The company reported the interim efficacy result from its registration-enabling clinical trial evaluating cosibelimab in patients with LA cSCC who are not candidates for curative surgery or radiation
- As of the Mar 2022 data cutoff, the therapy showed an ORR of 54.8% as determined by ICR in 31 patients, exceeding a clinically meaningful lower bound of the 95% two-sided confidence interval by 25%
- Cosibelimab is a fully-human mAb of IgG1 subtype that binds to PD-L1 and inhibits its interaction with the PD-1 and B7.1 receptors. The company plans to continue discussions with the US FDA about adding LA cSCC as a second indication with an expected BLA submission in 2022
Ref: Globe Newswire | Image: Checkpoint
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